Protein Synthesis and Memory - Springer
17/04/2014 · Protein Synthesis and ..
Anisomycin induces apoptosis of glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK.
An antibiotic that inhibits protein and DNA synthesis .
Although our results suggest that deficits caused by protein synthesis inhibition after memory retrieval reverse with time, deficits observed after initial acquisition appear to be long-lasting. This long-lasting impairment in acquisition has been observed in other studies with repeated anisomycin injections (), and the difference in persistence between initial acquisition and retrieval deficits also has been observed with other manipulations (, ). Of course, it is possible that the original acquisition memory was intact, but our method of unmasking that memory was unable to detect it. Indeed, as with putative deficits in reconsolidation, it is important to realize that there is no simple isomorphic relation between behavior and memory, meaning that the absence of a behavior should not by itself be taken as evidence for the absence of a memory. What is clear from our experiments is that the 21-day retention interval, although long enough to reverse a deficit after context retrieval, did not reverse a deficit after initial acquisition. These findings suggest that, at the very least, the effects of protein synthesis inhibition after acquisition and retrieval are quite different (, ).