Choe,"Total Synthesis of Cyclophellitol and(1
Strychnine total synthesis in chemistry ..
To illustrate the Type II ARC tactic in complex molecule synthesis, we first took on a modest challenge, the construction of a gorgonian sesquiterpene (-)-111 (), that possesses modest cytotoxicity against a variety of human cancer cell lines [IC50 values (mg/mL): 5.0 for A-549 (human lung carcinoma, 5.0 for HT-29 (human colon carcinoma, and 5.0 for MEL-28 (human melanoma)]. At the time the absolute configuration of (-)-111 had not been defined. Particularly attractive was the possibility of assembling the complete carbon skeleton of the sesquiterpene in a single Type II multi-component ARC reaction.
Rearrangements in Total Synthesis 3 1.1 ..
We have recently validated the power of the Type II multi-component ARC tactic both in complex molecule synthesis and in diversity oriented synthesis. Two synthetic and one DOS example from our laboratory will be presented.