T1 - Perspectives on the Amyloid-β Cascade Hypothesis
N2 - For the better part of the past two decades, studies on the molecular, biochemical and cellular mechanisms of Alzheimer disease have focused on amyloid-β protein, the major proteinaceous component of senile plaques. In fact, the Amyloid Cascade Hypothesis has come to dominate the field both in terms of proposed disease mechanism as well as potential for therapeutic intervention. In this review, we look at the Amyloid Cascade Hypothesis from the perspective of pathology, cell biology, and genetics. In all cases, alternate interpretations of old data as well as new evidence indicates that amyloid-β far from being the harbinger of disease, actually occurs secondary to more fundamental pathological changes and may even play a protective role in the diseased brain. These findings bring into serious doubt the validity of the Amyloid Cascade Hypothesis as the central cause of Alzheimer disease and, consequently, the potential usefulness of therapeutic targets against amyloid-β.
The Amyloid Cascade Hypothesis of Alzheimer's Disease?
Amyloid Cascade Hypothesis and Alzheimer's Disease - …
Dutch forum; Amyloidosis Foundation; Bacterial Inclusion Bodies Contain Amyloid-Like Structure outlines for argumentative essays at SciVee; Amyloid Cascade Hypothesis; the amyloid cascade hypothesis Stanford.
Alzheimer's disease: the amyloid cascade hypothesis | Science
104760 - amyloid beta a4 precursor protein; app - amyloid of aging and alzheimer disease; aaa;; cerebral vascular the amyloid cascade hypothesis amyloid peptide; cvap;; protease.