Oxirane, 2-ethyl-, polymer with oxirane, mono-C12-14-sec-alkyl ethers

Human data show that chemical agents, in particular drugs, can cause autoimmune diseases (Kammüller, Bloksma and Seinen 1989). There are a number of experimental animal models of human autoimmune diseases. Such comprise both spontaneous pathology (for example systemic lupus erythematosus in New Zealand Black mice) and autoimmune phenomena induced by experimental immunization with a cross-reactive autoantigen (for example the H37Ra adjuvant induced arthritis in Lewis strain rats). These models are applied in the preclinical evaluation of immunosuppressive drugs. Very few studies have addressed the potential of these models for assessment of whether a xenobiotic exacerbates induced or congenital autoimmunity. Animal models that are suitable to investigate the ability of chemicals to induce autoimmune diseases are virtually lacking. One model that is used to a limited extent is the popliteal lymph node assay in mice. Like the situation in humans, genetic factors play a crucial role in the development of autoimmune disease (AD) in laboratory animals, which will limit the predictive value of such tests.

Oxirane, 2-ethyl-, polymer with oxirane, mono-C11-15-sec-alkyl ethers

Feron, Central Institute for Food Research, Zeist, Netherlands (Chapter 5) a Dr P.
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Oxirane, alkyl-, homopolymer, 3-aminopropyl 4-dodecylphenyl ether

Comparison between the mutagenic action of the compound on a test strain directly and the host-mediated assay indicates whether the host can activate or inactivate the test compound.

Formaldehyde, polymer with (chloromethyl)oxirane and phenol

Further studies on the alteration of DNA induced by chemical carcinogens and on the repair of such lesions before cell division by tissues, whether target or not, are required to evaluate the role of DNA repair processes in chemical carcinogenesis.

Kroes, Central Institute for Nutrition & Food Research, Zeist, Netherlands (Chapters 1 & 5) Dr J.
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Triethylene glycol diglydicyl ether ()

1.4.2 Need for human investigations Although there is general repugnance at the idea of using human subjects to assess the safety of environmental chemicals, the question is not whether or not human subjects should be used in toxicity experiments but rather whether such chemicals, deemed from animal toxicity studies to be relatively safe, should be released first to controlled, carefully monitored groups of human subjects, instead of being released indiscriminately to large populations with no monitoring and with little or no opportunity to observe adverse effects (Paget, 1970).

Alkyl(C16-18)polyethyleneglycol tetra decylene glycolether

Three particular aspects of human toxicology have need of such information, namely: (a) the selection, through comparative consideration of metabolism, of the most appropriate animal species for studies to predict the human response; (b) investigation of a specific, reversible effect of the compound in the most sensitive animal species, to determine whether there is a correlation with a similar effect in man; and (c) study of effects specific to man.

Diglycidyl resorcinol ether ()

Whether a given organ or system is regarded as critical depends not only on the toxicomechanics of the hazardous agent but also on the route of absorption and the exposed population.

Bis(2-chloro-1-methylethyl)ether ()

(1975) recently reported a high incidence of respiratory tract tumours in rats after exposure to oxybis[chloro-methane] (bis(chloromethyl)ether) but only a few tumours in hamsters.

Bisphenol A diglycidyl ether () (1989)

Hexanedioic acid, polymer with N-(2-aminoethyl)-N′-[2-[(2-aminoethyl)amino]ethyl]-1,2-ethanediamine, N-(2-aminoethyl)-1,2-ethanediamine and (chloromethyl)oxirane, sulfate