Synthesis of Chloroquine | vitoribecco2013's Blog

Addition of hemin plus glucose 6-phosphate or highconcentrations of GTP, cAMP, and an active preparation of eIF-2 to theparasite cell-free system restores protein synthesis to a significantextent in chloroquine-treated cultures.

Synthesis of New Chloroquine Derivatives as …

Chloroquine inhibits the heme-dependent proteinsynthesis in the parasite lysate.

Synthesis and Evaluation of Chloroquine-Containing …

AB - The effects of chloroquine and primaquine on aminoacylation and polypeptide synthesis in subcellular rat liver systems were investigated. Both drugs exhibited concentration-dependent inhibition of phenylalanine incorporation into aminoacyltRNA. Under conditions where the phenylalanyl-14C-tRNA concentration remained at a "steady state" level, even in the presence of chloroquine or primaquine, the poly U-dependent polyphenylalanine synthesis exhibited concentration-related inhibition by the drugs. When choroquine or primaquine was added several minutes after addition of poly U, the inhibition was not abolished. The drugs did not bring about premature chain termination. Both chloroquine and primaquine inhibited peptidyl transferase, as measured by transfer of polypeptide to puromycin-3H.

A new synthesis of chloroquine - ResearchGate

N2 - The effects of chloroquine and primaquine on aminoacylation and polypeptide synthesis in subcellular rat liver systems were investigated. Both drugs exhibited concentration-dependent inhibition of phenylalanine incorporation into aminoacyltRNA. Under conditions where the phenylalanyl-14C-tRNA concentration remained at a "steady state" level, even in the presence of chloroquine or primaquine, the poly U-dependent polyphenylalanine synthesis exhibited concentration-related inhibition by the drugs. When choroquine or primaquine was added several minutes after addition of poly U, the inhibition was not abolished. The drugs did not bring about premature chain termination. Both chloroquine and primaquine inhibited peptidyl transferase, as measured by transfer of polypeptide to puromycin-3H.

Ribosomes as well as the S-100fraction isolated from such chloroquine-treated cultures are defectivein protein synthesis.

Pharma Synthesis - Multi-step synthesis

Chloroquine-containing 2-(dimethylamino)ethyl methacrylate copolymers (PDCs) are synthesized by reversible addition-fragmentation chain-transfer polymerization. Systematic evaluation is performed to test the hypothesis that presence of chloroquine (CQ) in the PDC structure will improve miRNA delivery due to enhanced endosomal escape while simultaneously contribute to anticancer activity of PDC/miRNA polyplexes through inhibition of cancer cell migration. The results show that miRNA delivery efficiency is dependent both on the molecular weight and CQ. The best performing PDC/miRNA polyplexes show effective endosomal escape of miRNA. PDC polyplexes with therapeutic miR-210 show promising anticancer activity in human breast cancer cells. PDC/miRNA polyplexes show excellent ability to inhibit migration of cancer cells. Overall, this study supports the use of PDC as a promising polymeric drug platform for use in combination anti-metastatic and anticancer miRNA therapeutic strategies.

| The important antimalarial, chloroquine (I), has been synthesized by a new scheme

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It is proposed that chloroquine inhibitsheme-dependent protein synthesis in the parasite and this is an earlyevent mediating the growth-inhibitory effects of the drug.

Structure, properties, spectra, suppliers and links for: Chloroquine.

AB - Chloroquine-containing 2-(dimethylamino)ethyl methacrylate copolymers (PDCs) are synthesized by reversible addition-fragmentation chain-transfer polymerization. Systematic evaluation is performed to test the hypothesis that presence of chloroquine (CQ) in the PDC structure will improve miRNA delivery due to enhanced endosomal escape while simultaneously contribute to anticancer activity of PDC/miRNA polyplexes through inhibition of cancer cell migration. The results show that miRNA delivery efficiency is dependent both on the molecular weight and CQ. The best performing PDC/miRNA polyplexes show effective endosomal escape of miRNA. PDC polyplexes with therapeutic miR-210 show promising anticancer activity in human breast cancer cells. PDC/miRNA polyplexes show excellent ability to inhibit migration of cancer cells. Overall, this study supports the use of PDC as a promising polymeric drug platform for use in combination anti-metastatic and anticancer miRNA therapeutic strategies.

block the enzymatic synthesis of DNA and RNA

N2 - Chloroquine-containing 2-(dimethylamino)ethyl methacrylate copolymers (PDCs) are synthesized by reversible addition-fragmentation chain-transfer polymerization. Systematic evaluation is performed to test the hypothesis that presence of chloroquine (CQ) in the PDC structure will improve miRNA delivery due to enhanced endosomal escape while simultaneously contribute to anticancer activity of PDC/miRNA polyplexes through inhibition of cancer cell migration. The results show that miRNA delivery efficiency is dependent both on the molecular weight and CQ. The best performing PDC/miRNA polyplexes show effective endosomal escape of miRNA. PDC polyplexes with therapeutic miR-210 show promising anticancer activity in human breast cancer cells. PDC/miRNA polyplexes show excellent ability to inhibit migration of cancer cells. Overall, this study supports the use of PDC as a promising polymeric drug platform for use in combination anti-metastatic and anticancer miRNA therapeutic strategies.