Synthesis of Chiral Difluorinated (6)-Gingerol
-Gingerol inhibits nitric oxide synthesis in activated J774
The present study was aimed at discovering novel biologically active compounds based on the skeletons of gingerol and shogaol, the pungent principles from the rhizomes of Zingiber officinale. Therefore, eight groups of analogues were synthesized and examined for their inhibitory activities of platelet aggregation induced by arachidonic acid, collagen, platelet activating factor, and thrombin. Among the tested compounds, -paradol (5b) exhibited the most significant anti-platelet aggregation activity. It was the most potent candidate, which could be used in further investigation to explore new drug leads.
Synthesis process of gingerol derivative
"Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): Identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases".
Functional use(s) - cosmetic, flavor and fragrance agents
The dose thereof for adults is up to 3 times a day based on 20-80mg at a time as an oral agent and 0.25-10mg a month as a parenteral agent.
PRODUCTION OF GINGEROL AND SHOGAOL
PURPOSE:To industrially and simply obtain gingerol useful as a synthetic intermediate for shogaol, a perfume composition, etc., by reacting a specific gingerone with an aldehyde.
citral, 5392-40-5 - The Good Scents Company
Platelets circulate in the blood of mammals and are involved in hemostasis, leading to the formation of blood clots. Too many platelets form blood clots that may obstruct blood vessels and induce strokes, myocardial infarctions, and pulmonary embolisms. Sometimes this situation also results in the blockage of blood vessels to other parts of the body, including the extremities of the arms or legs . The traditional medicinal use of ginger is to promote the blood circulation necessary for removing blood stasis. Therefore, synthetic derivatives were examined in the anti-platelet aggregation bioassay to test for the presence of activity. The anti-platelet aggregation results are summarized in –. All the tested compounds displayed significant inhibitory effects on the aggregation of washed rabbit platelets stimulated by arachidonic acid (AA). At a 10 μg/mL concentration, most of the tested compounds with the exception of 3a, 3d, and 7e caused the inhibition percentages of aggregation induced by AA (100 μM) to be higher than 90%. On the other hand, the activities of these synthetic derivatives against platelet activating factor (PAF) and thrombin (Thr) induced aggregation were insignificant.