Various laboratory methods exist for the of thiazoles.
The reactivity of a thiazole can be summarized as follows:
SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-HYDRAZONO-2(3H)-THIAZOLE DERIVATIVES DERIVED FROM 4-(3-CHLOROPHENYL)-3-THIOSEMICARBAZIDE
Rambaldi, “Novel thiazole derivatives: A patent review (2008 - 2012.
De Aquino TM, Liesen AP, da Silva REA, Lima VT, Carvalho CS, de Faria AR, et al. Synthesis, anti-Toxoplasma gondii and antimicrobial activities of benzaldehyde 4-phenyl-3-thiosemicarbazones and 2-[(phenylmethylene)hydrazono]-4-oxo-3-phenyl-5-thiazolidineacetic acids. Bioorg Med Chem 2008;16:446-56.
(3 H )-thiazoles in excellent yields
Starting from -alanine, bacillamide C (3), was obtained in 22% overall yield . The key intermediate, thiazole 35, , was synthesized using Hantzsch reaction.
Etude du mécanisme de la reaction de hantzsch des thiazoles
When a base is added in solution, a drastic change of absorption and of fluorescence is observed. The lactone ring-opening process leads to deprotonated 4-hydroxythiazoles, which, due to their electronically altered π-systems, display fluorescence in the orange to red region of the visible spectrum. Derivatives ,, and, which form pyridinium ions and compounds , which contain an additional aza-nitrogen in the neighboring pyridine ring, show a strong green fluorescence upon the addition of acids. A geometry change is discussed as a reason for this unusual shift.
Define thiazole | Dictionary and Thesaurus
During 2009, six reports related to the synthesis of largazole and/or analogs were published [–]. A significant increase in potency with a pyridine substitution of the thiazole was reported. In addition, it was demonstrated that the methyl substituent of the thiazoline ring is nonessential for the dramatic potency of the natural product. In contrast, substitution of the thiazoline by thiazol, diminishes the activity .