Examples of Hypothesis Testing - YourDictionary
N2 - Previous reports have suggested that the abrogation of gastric inhibitory polypeptide (GIP) signaling could be exploited to prevent and treat obesity and obesity-related disorders in humans. This study was designed to determine whether immunoneutralization of GIP, using a newly developed specific monoclonal antibody (mAb), would prevent the development of obesity. Specific mAb directed against the carboxy terminus of mouse GIP was identified, and its effects on the insulin response to oral and to intraperitoneal (ip) glucose and on weight gain were evaluated. Administration of mAb (30 mg/kg body wt, BW) to mice attenuated the insulin response to oral glucose by 70% and completely eliminated the response to ip glucose coadministered with human GIP. Nine-week-old C57BL/6 mice injected with GIP mAbs (60 mg·kg BW−1·wk−1) for 17 wk gained 46.5% less weight than control mice fed an identical high-fat diet (P 0.001). No significant differences in the quantity of food consumed were detected between the two treatment groups. Furthermore, magnetic resonance imaging demonstrated that subcutaneous, omental, and hepatic fat were 1.97-, 3.46-, and 2.15-fold, respectively, lower in mAb-treated animals than in controls. Moreover, serum insulin, leptin, total cholesterol (TC), low-density lipoprotein (LDL), and triglycerides were significantly reduced, whereas the high-density lipoprotein (HDL)/TC ratio was 1.25-fold higher in treated animals than in controls. These studies support the hypothesis that a reduction in GIP signaling using a GIP-neutralizing mAb might provide a useful method for the treatment and prevention of obesity and related disorders.
Examples of hypothesis testing include testing the effect of ..
Child obesity - Encyclopedia on Early Childhood Development
The following sections of this article will present arguments and evidence in support of the above assumptions and hypotheses. Other evolutionary theories for eating disorders will be briefly reviewed and will be contrasted with the present hypothesis and a number of predictions based upon this hypothesis will be made. Figure 1 presents a brief outline of the reasoning behind the present hypothesis.
Critical periods in childhood for the development of obesity.
The increasing prevalence of childhood obesity, ranked as a critical public-health problem in the 21st century, has led policy-makers in several countries to take preventive actions. The responsibility for obesity prevention among young children lies not only in the hands of parents and families but also in the hands of national governments, local governments, communities, non-profit organizations, the food industry, the media, and schools and local education authorities.
10/06/2014 · The Estrogen Hypothesis of Obesity
Childhood obesity is associated with a wide range of disorders that affect multiple organ systems. Increased body weights in children may lead, for instance, to insulin resistance, glucose intolerance, hypertension, and orthopaedic problems.1 Some of these conditions produce clinical symptoms in the patient, while others do not. The physiologic and metabolic changes associated with obesity in children tend to follow them into adult life and increase the risks for disease, disability, and death.