Isocyanide synthesis by substitution

Synthesis and characterization studies of mono and disubstituted isocyanide complexes of iron and ruthenium are being conducted by Professor Shade under both thermal and photochemical conditions. The identity of incoming Lewis bases such as phosphine or phosphite ligands, solvent identity, reaction temperature and wavelength of the photolysis lamp are all under investigation as variables which affect the identity and ratio of reaction products. Through collaborative efforts with colleagues in England and Idaho, frozen matrix isolation studies are being conducted at 12K to investigate the cyano-isocyanide intermediates generated in these reactions. In a separate project, the incorporation of resolved prophos ligand into cyclopentadienyl iron and ruthenium complexes is under study with an emphasis on the characterization of the diastereomeric products. Other projects underway in Professor Shade's laboratory and research collaborations involve 1) the synthesis and structural characterization of ditertiary phosphine derivatives of tetracarbonyldi-n5-cyclopentadienyliron and ruthenium; 2) the generation of metal radicals as intermediates in organometallic synthesis; 3) the syntheses and photochemical rearrangements of ring coupled bimetallic compounds; and 4) the syntheses and characterization of bidentate complexes of iron and ruthenium via photochemical Reimer-Tieman reactions.

Isocyanide Synthesis with Diphosgene - ResearchGate

Isocyanide-based multicomponent reactions can be used to synthesize a diverse array ..

Isocyanide chemistry : applications in synthesis and material science

N2 - A bidentate monoanionic NHC-CAryl ligand framework was synthesized, and a host of Ni(II) complexes were prepared. Addition of isocyanides to these complexes led to the formation of NHC-n2-iminoacyl nickel complexes. These complexes were characterized by a suite of spectroscopic techniques, including X-ray crystallography. The n2-iminoacyl was shown to be displaced from the nickel center with oxidant and could then be reattached with reductant.

ISOCYANIDE SYNTHESIS - Defense Technical …

AB - A bidentate monoanionic NHC-CAryl ligand framework was synthesized, and a host of Ni(II) complexes were prepared. Addition of isocyanides to these complexes led to the formation of NHC-n2-iminoacyl nickel complexes. These complexes were characterized by a suite of spectroscopic techniques, including X-ray crystallography. The n2-iminoacyl was shown to be displaced from the nickel center with oxidant and could then be reattached with reductant.

Methods - Synthesis & Techniques

AB - The cytochromes P450 (CYPs) play a central role in a variety of important biological oxidations, such as steroid synthesis and the metabolism of xenobiotic compounds, including most drugs. Because CYPs are frequently assayed as drug targets or as anti-targets, tools that provide con firmation of active-site binding and information on binding orientation would be of great utility. Of greatest value are assays that are reasonably high throughput. Other heme proteins, too-such as the nitric oxide synthases (NOSs), with their importance in signaling, regulation of blood pressure, and involvement in the immune response-often display critical roles in the complex functions of many higher organisms, and also require improved assay methods. To this end, we have developed an analog of cyanide, with a 13CH3 -reporter group attached to make methyl isocyanide. We describe the synthesis and use of 13C-methyl isocyanide as a probe of both bacterial (P450cam) and membrane-bound mammalian (CYP2B4) CYPs. The 13C-methyl isocyanide probe can be used in a relatively high-throughput 1-D experiment to identify binders, but it can also be used to detect structural changes in the active site based on chemical shift changes, and potentially nuclear Overhauser effects between probe and inhibitor.

Isocyanides are valuable tools for the preparation of ..

The first isocyanide, isocyanide was prepared in 1859 by the chemist Lieke from thereaction of iodide and .Normally the of an alkali metal cyanide givesa nitrile, but the silver ion protects the carbon end of thecyanide. Commonly, isocyanides are synthesized by the reaction ofprimary with or by of a with .

Toluenesulphonylmethyl isocyanide (TOSMIC) and the …

The Hofmann isocyanide synthesis is a forprimary based on theirreaction with and as precursors to foul smelling isocyanides.