Magnesium Flakes from Ancient Minerals - …
Glossary | Linus Pauling Institute | Oregon State University
The synthesis of cholesterol depends on magnesium, as noted. Despite health conditions related to its overproduction, cholesterol is a vital component of many hormones. For example, magnesium is needed for the production of aldosterone, which notably regulates the balance of magnesium and other minerals in the body (Transdermal 237). It therefore may be seen that cholesterol is the mother of hormones produced in the adrenal cortex, including cortisone, hydrocortisone, aldosterone, and DHEA (dehydroepiandrosterone).
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Magnesium regulates blood cholesterol by playing a pivotal role in the function of the enzyme responsible for its synthesis in the body. This enzyme is known as HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-CoA reductase). Magnesium deactivates this enzyme, which is the rate-limiting enzyme controlling the conversion of HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA) into the compound mevalonate (a fatty acid derivative). When this first step in the mevalonate pathway is inhibited by the deactivation of HMG-CoA reductase by magnesium and ATP (magnesium-ATP complex), then cholesterol production correspondingly is reduced (Seelig 127). The final result is less formation of cholesterol. Magnesium regulates cholesterol synthesis by deactivating the enzyme necessary for producing it!
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Dr. Norman Shealy reports that magnesium chloride gradually increases natural DHEA levels, especially when applied transdermally. He suggests that when the body is provided with adequate levels of magnesium at the cellular level, it naturally begins to produce higher levels of DHEA and DHEA-S (Transdermal 238-39). Because the body can convert DHEA to testosterone, many benefits of increased DHEA production likely are due to the effects of testosterone. Optimal testosterone levels play an important role in many body functions, including maintaining muscle mass and bone density, regulation of blood sugar, uptake of oxygen by cells, immune system function, red blood cell production, maintaining cardiac muscle, neurological function, and sexual desire (and performance) (Transdermal 240). Testosterone, for example, is the hormone most closely associated with healthy sex drive in men and women. Increased libido in women is among the reported effects of transdermal magnesium therapy.