1-FLUORO-4-NITROBENZENE FOR SYNTHESIS | …
It is a colorless hygroscopic liquid with a strong odor
In an hepatocyte DNA repair test, rats were gavaged with nitrobenzene at 200 or 500 mg/kg of body weight and killed after 12 h; their livers were then removed, and primary cultures of hepatocytes were incubated with [3H]thymidine. There was no evidence of any increase in unscheduled DNA synthesis (Mirsalis et al., 1982).
Tetrazole synthesis - Organic chemistry
Based on air studies and on estimates of releases during manufacture, only populations in the vicinity of manufacturing activities (i.e., producers and industrial consumers of nitrobenzene for subsequent synthesis) and petroleum refining plants are likely to have any significant exposure to nitrobenzene (see section 5.1). However, consideration of possible groundwater (see section 5.1.2) and soil contamination (see section 5.1.4) and uptake of nitrobenzene by plants (see section 4.3.2) expands the population with the potential for higher exposures to those people living in and around abandoned hazardous waste sites.
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From available records, it is apparent that there has been a significant increase in annual production of nitrobenzene over the past 30–40 years. Most is retained in closed systems for use in further synthesis, particularly of aniline, but also of substituted nitrobenzenes and anilines. Losses during production of nitrobenzene are likely to be low; when nitrobenzene is used as a solvent, however, emissions may be higher. Nitrobenzene has been shown to be emitted from sewage sludge incineration units and has been measured in air at hazardous waste landfills.