Methods in Organic Synthesis - RSC Publishing Home
Organic synthesis is a special part of chemical synthesis
But if the goal of organic synthesis is to synthesize a molecule, then it does reduce in that way. That’s where many people have a problem, because it feels wrong to them in the same way that brute-forcing to the end of a chess game does. So that starts a search for other goals – training chemists, discovering new reactions, and many more – some of which are good arguments and some of which aren’t. I think, though, that the listing of them comes from that initial feeling of strange wrongness that people get when they envision hitting a “start” button for a program to optimize a retrosynthesis, which then starts a hood full of robot parts to cranking out the molecule – while the chemist does what, exactly? If chess is just two computer programs banging into each other, what’s the point, and if organic synthesis reduces to a pile of algorithms and a bunch of tubing and pumps. . .?
It builds organic compounds using organic reactions
Phillip Ball has at Nature on the future of organic synthesis (and quotes a number of times from discussions on this blog). He starts off with the reasons why people go to the trouble of making molecules in the first place, looks at how that process has changed over the years (and how the reasons behind it have), and at where both of those might be going.
hexanes are flammable organic solvents
I am thankful of the giants (such Johnson, Woodwrod, Corey to name a few) that revitalized and forged their way in the age of where we did not have any of the sophisticated tools that we have today for synthesis, purification and characterizations. My labmates always ponder upon this as we are lazy to make couple of NMR samples and go run the NMRs to see what we have made……To me it appears that every one is failing to see the big picture, central nature, and utility of organic synthesis is because there is no funding for it and it is laborious. If tomorrow NIH and NSF announces couple of big initiatives of funding for organic synthesis, I am sure many universities would ask people such as Prof. Albert Padwas to come out of retirement and occupy the while research building………money rules everywhere……the only field that is reproducible (forget about 10% discrepancy in the yields!) and in creation of the biologically important molecules is OS. I pity those who can’t see the beauty, scinece and art of it. I am glad that I am graduating at times from synthesis group where I do not have to compete with bunch of people that have the same skill set, and mental and intellectual ability. I am going to learn other fields to ride on what I’ve already mastered which is hard for many people.