Organic Synthesis Collection: R: ..
Published by Organic Syntheses, Inc.
Synthesis of β-nitrostyrene derivatives and their following reactions through two-step continuous-flow protocols with heterogeneous catalysts are described. In the first step to provide β-nitrostyrenes from aromatic aldehydes and nitromethane, readily available amino-functionalized silica gel was employed as a catalyst and gave the products continuously for at least 100 h with high selectivity. In the second step, reactions of β-nitrostyrenes, solid bases, immobilized bases, solid acids, and chiral supported metals and nonmetals were used as catalysts, and seven kinds of nitro-containing organic compounds could be effectively synthesized through the two-step continuous-flow systems.
Pyrrole synthesis - Organic chemistry
The use of polymer-supported reagents and scavengers provides an attractive and practical method for the clean and efficient preparation of novel chemical entities. These methods can be extended in a multistep fashion to provide access to more complex structures, including biologically active natural products. In our we covered all known supported reagents, catalysts and scavenging agents as useful directory to assist with future synthesis planning in the chemical community. Our group has a long track record in the development and application of polymer-supported reagents in organic synthesis and here we provide a few examples of our work in this area.