Worrall, D. E. 2003. Nitrostyrene. Organic Syntheses. 66.

trans-4-Methyl-β-nitrostyrene may be used as a reagent in the synthesis of N-benzylpyrrolomorphinans. It is also used as an organic intermediate for pharmaceutical.

Organic Synthesis Collection: R: ..

Methods - Synthesis & Techniques > Organic Syntheses > Abstract; DATABASE TOOLS

Published by Organic Syntheses, Inc.

Synthesis of β-nitrostyrene derivatives and their following reactions through two-step continuous-flow protocols with heterogeneous catalysts are described. In the first step to provide β-nitrostyrenes from aromatic aldehydes and nitromethane, readily available amino-functionalized silica gel was employed as a catalyst and gave the products continuously for at least 100 h with high selectivity. In the second step, reactions of β-nitrostyrenes, solid bases, immobilized bases, solid acids, and chiral supported metals and nonmetals were used as catalysts, and seven kinds of nitro-containing organic compounds could be effectively synthesized through the two-step continuous-flow systems.

Pyrrole synthesis - Organic chemistry

The use of polymer-supported reagents and scavengers provides an attractive and practical method for the clean and efficient preparation of novel chemical entities. These methods can be extended in a multistep fashion to provide access to more complex structures, including biologically active natural products. In our we covered all known supported reagents, catalysts and scavenging agents as useful directory to assist with future synthesis planning in the chemical community. Our group has a long track record in the development and application of polymer-supported reagents in organic synthesis and here we provide a few examples of our work in this area.

Reactions > Organic Synthesis ..
Nitroalkanes are very important intermediates in organic synthesis as ..

Reduction methods in organic synthesis , Hive …

Gold-catalyzed hydroamination has been applied to the synthesis of indoles. In the presence of electrophiles, the organogold intermediates of this reaction may react further to establish substituents at the 3-position of the indole ring (Eq. 15).

metal-catalysed hydroboration is a reaction used in organic synthesis .

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N2 - The epoxide hydrolase activity of Aspergillus niger was synthesized during growth of the fungus and was shown to be associated with the soluble cell fraction. An enzyme preparation was worked out which could be used in place of the whole mycelium as biocatalyst for the hydrolysis of epoxides. The effect of four different cosolvents on enzyme activity was investigated. Consequently, dimethylsulfoxide (DMSO) was selected for epoxide solubilization. The effect of temperature on both reaction rate and enzyme stability was studied in the presence of DMSO (0.2 volume ratio). A temperature of 25°C was selected for the reaction of bioconversion. With a substrate concentration of 4.5 mM a batch reactor showed that the enzyme preparation hydrolyzed para-nitrostyrene oxide with very high enantioselectivity. The (S) enantiomer of the epoxide remained in the reaction mixture and showed an enantiomeric excess higher than 99%. The substrate concentration could be increased to 20 mM without affecting the enantiomeric excess and degree of conversion. Therefore, the method is potentially useful for the preparative resolution of epoxides. Application are in the field of chiral synthons which are important building blocks in organic synthesis.

of benzaldehyde (Note 1), and 1000 cc

AB - The epoxide hydrolase activity of Aspergillus niger was synthesized during growth of the fungus and was shown to be associated with the soluble cell fraction. An enzyme preparation was worked out which could be used in place of the whole mycelium as biocatalyst for the hydrolysis of epoxides. The effect of four different cosolvents on enzyme activity was investigated. Consequently, dimethylsulfoxide (DMSO) was selected for epoxide solubilization. The effect of temperature on both reaction rate and enzyme stability was studied in the presence of DMSO (0.2 volume ratio). A temperature of 25°C was selected for the reaction of bioconversion. With a substrate concentration of 4.5 mM a batch reactor showed that the enzyme preparation hydrolyzed para-nitrostyrene oxide with very high enantioselectivity. The (S) enantiomer of the epoxide remained in the reaction mixture and showed an enantiomeric excess higher than 99%. The substrate concentration could be increased to 20 mM without affecting the enantiomeric excess and degree of conversion. Therefore, the method is potentially useful for the preparative resolution of epoxides. Application are in the field of chiral synthons which are important building blocks in organic synthesis.