Postdoctoral Fellow in Materials Chemistry - Neutron Scattering ..
Post-doctoral position in Ye Jian ..
cfaed is a cluster of excellence within the German Excellence Initiative. As a central scientific unit of TU Dresden, it brings together 300 researchers from the university and 10 other research institutes in the areas of Electrical and Computer Engineering, Computer Science, Materials Science, Physics, Chemistry, Biology, and Mathematics. cfaed addresses the advancement of electronic information processing systems through exploring new technologies which overcome the limits of today's predominant CMOS technology.
Postdoctoral position in computational biology
Inspired by the tautomeric relationship of imidazole and N-heterocyclic carbenes, we have been intrigued about the implications of such carbenes in metalloenzymes. Enzymes are the machinery of all biological transformations, and provide inspiration for designing artificial catalysts. New insights into the mode of action of enzymes is therefore instrumental for developing more competent synthetic catalysts as well as for better understanding natural systems. In collaboration with F. Paradisi (U Nottingham), we have begun to explore carbene binding to metalloenzymes. We have been focusing on blue copper proteins such as azurin and specific mutants of azurin to investigate the possibility of carbene bonding to the copper center, and to evaluate the effect that such bonding entails. While azurin is predominantly involved in electron transfer processes through reversible copper(II) reduction and oxidation, other blue copper proteins are catalytically active in redox transformations of substrates. Hence, these enzymes provide an attractive probe to explore the relevance of carbene bonding on the catalytic performance of the enzyme.