In a typical synthesis, Pt(acac)2 ..

The PMR spectra of a solution of Pt (NO2-acac) 2 (0.1M) in pyridine or quinoline have been recorded in the beginning and after a lapse of several hours. The CH3 proton chemical shifts of Pt (NO2-acac) 2 in different solvents are listed in Table 2. In the same table the proton chemical shift of Pt (NO2-acac) 2 in an inert solvent (CCl4) has been reported. Though, some higher field shift in –CH3 proton on complexation of Pt(NO2-acac)2 with pyridine is expected due to the charge-transfer from n-orbital of the base to a vacant II-orbital of the acceptor chelate ring. But, no appreciable change in it was observed (Table 2). Further, an interesting splitting in –CH3 proton chemical shift after keeping this reaction mixture for about 20 hours was observed. This may be due to the interaction of n-orbital of pyridine with vacant II-orbital of chelate ring, which creates the-CH3 proton in different electronic environment and thus disturbs the symmetry of the chelate rings. In the case of quinoline an appreciable change in the –CH3 proton chemical shift to higher field is observed (+14 Hz) which is according to expectation spitting in the –CH3 proton chemical shift has also been noticed like pyridine.

(CO)5 and sequential reduction of Pt(acac)2 (acac ..

Table 2: Proton Chemical Shifts of Pt (NO2-acac)2 in Different Electronic Environments

we obtained via sol–gel process Pt(acac) 2 ..

AB - In the field of experimental oncology, many efforts are being carried out to search new platinum-based drugs overcoming the CNS toxicity and drug resistance. One of the adopted strategies is the synthesis of platinum compounds able to form Pt-DNA adducts different from the cisplatin ones or to react with other subcellular targets. In this context a novel Pt(II) complex, [Pt(O,O'-acac)(γ-acac)(DMS)](PtAcacDMS), was synthesized which reacts preferentially with protein thiols or thioethers. In this work we investigated the in vivo effects of cisplatin and PtAcacDMS on normal development. Moreover, to verify the dose-dependence of the effects, different groups of animals were treated with 5 μg/g or 10 μg/g body weight of cisPt and PtAcacDMS. We have focused our attention on the cerebellum because it provides a useful model system to evaluate the outcomes of perinatal treatment with chemotherapeutic agents on key CNS developmental processes such as neural cells proliferation, migration and differentiation. We have demonstrated the ability of both cisPt and PtAcacDMS to reach the brain tissue once injected. The brain platinum content after PtAcacDMS treatment was notably higher (approximately 4-fold as much) than after cisPt. The platinum accumulation in the brain was still considerable 7. days after PtAcacDMS administration. However, compared with cisplatin, PtAcacDMS induces less severe changes on fundamental events of neuroarchitecture development, such as no high apoptotic events, less altered granule cell migration and Purkinje cell dendrite growth, suggesting a low neurotoxicity of this new Pt complex for normal CNS. The mild damages could be attributable to the different subcellular target of this compound as well as to a greater efficiency of the cell repair system to recognize the drug-target adducts and to repair them. Together with the previously demonstrated antineoplastic effectiveness in vitro, the findings here reported suggest PtAcacDMS as a potential alternative to cisplatin indicating, at the same time, that the choice of platinum compounds with new subcellular targets could be a strategy to prevent neurotoxicity induced by cisplatin and overcome drug resistance induced by mutations in the intrinsic apoptotic pathway.

Synthesis of Co Acac 3 Essay - 1062 Words - StudyMode

N2 - In the field of experimental oncology, many efforts are being carried out to search new platinum-based drugs overcoming the CNS toxicity and drug resistance. One of the adopted strategies is the synthesis of platinum compounds able to form Pt-DNA adducts different from the cisplatin ones or to react with other subcellular targets. In this context a novel Pt(II) complex, [Pt(O,O'-acac)(γ-acac)(DMS)](PtAcacDMS), was synthesized which reacts preferentially with protein thiols or thioethers. In this work we investigated the in vivo effects of cisplatin and PtAcacDMS on normal development. Moreover, to verify the dose-dependence of the effects, different groups of animals were treated with 5 μg/g or 10 μg/g body weight of cisPt and PtAcacDMS. We have focused our attention on the cerebellum because it provides a useful model system to evaluate the outcomes of perinatal treatment with chemotherapeutic agents on key CNS developmental processes such as neural cells proliferation, migration and differentiation. We have demonstrated the ability of both cisPt and PtAcacDMS to reach the brain tissue once injected. The brain platinum content after PtAcacDMS treatment was notably higher (approximately 4-fold as much) than after cisPt. The platinum accumulation in the brain was still considerable 7. days after PtAcacDMS administration. However, compared with cisplatin, PtAcacDMS induces less severe changes on fundamental events of neuroarchitecture development, such as no high apoptotic events, less altered granule cell migration and Purkinje cell dendrite growth, suggesting a low neurotoxicity of this new Pt complex for normal CNS. The mild damages could be attributable to the different subcellular target of this compound as well as to a greater efficiency of the cell repair system to recognize the drug-target adducts and to repair them. Together with the previously demonstrated antineoplastic effectiveness in vitro, the findings here reported suggest PtAcacDMS as a potential alternative to cisplatin indicating, at the same time, that the choice of platinum compounds with new subcellular targets could be a strategy to prevent neurotoxicity induced by cisplatin and overcome drug resistance induced by mutations in the intrinsic apoptotic pathway.

Structure for the interaction of Pt (NO2-acac)2 with pyridine is given below (Fig 3)
T1 - Synthesis and application of RuSe2 + δ nanotubes as a methanol tolerant electrocatalyst for the oxygen reduction reaction

Pt precursor, [Pt(acac)(NHR)] n (n = 2 ..

AB - (FeyPt100-y)100-xCux nanoparticles with various compositions were synthesized by the simultaneous polyol reduction of Pt(acac)2 and Cu(acac)2 and the thermal decomposition of Fe(CO)5. The as-made particles had a disordered fee structure and an average diameter of ∼4.8 nm. The result of x-ray diffraction indicated a transformation from fee structure to fct structure in some samples after annealing at 400 °C for 1 h, and the c/a ratio of lattice constant decreased with increasing Cu content. The doping of Cu clearly plays a significant role on the reduction of the ordering temperature in the ternary (FeyPt100-y)100-xCUx alloy. In addition, the ordering of (FeyPt100-y) 100-xCux nanoparticles is significantly dependent on the composition of Fe and Pt. As a result, (Fe47Pt53) 74Cu26 nanoparticles have the coercive fields of ∼10 and ∼2 kOe at 10 K and room temperature, respectively.

T1 - (Tetrathiafulvalene)Bis(Acetylacetonato)Paliiadium(II), (TTF)Pd(acac)2, a Metallotetrathiaethylene Containing Neutral Tetrathiafulvalene

Fan, H.; Sun, S., 2006: Synthesis of FePt nanocubes ..

We report a facile synthesis of hard magnetic L10-FePtAu nanoparticles by coreduction of Fe(acac)3, Pt(acac)2 (acac = acetylacetonate) and gold acetate in oleylamine. In the current reaction condition, NP sizes are controlled to be 5.5 to 11.0 nm by changing the amount of Au doping. When the Au composition in the NPs is higher than 14%, the hard magnetic NPs are directly obtained without any annealing. The highest coercivity of 12.15 kOe at room temperature could be achieved for the NPs with 32% Au doping, which is much higher than the coercivities reported by the previous studies on solution-synthesized FePt nanoparticles. The reported one-pot synthesis of L10-FePtAu NPs may help to build superstrong magnets for magnetic or data-storage applications.

Synthesis, characterization and in vitro cytotoxicity of Pt-TiO2 nanoparticles

28/01/2013 · Synthesis, optoelectronic ..

It has been shown by various workers [,] that aromatic nitro compounds from highly colored adducts with various bases and the behavior of Pt (NO2-acac) 2 is somewhat similar to the aromatic nitro compounds, thereby providing support on pseudo-aromatic character to these chelate rings. Although Dielectric, Conductometric, treatment of hard soft acid and base studies, towards solving the problems of aromaticity in metal acetylacetonates and nature of bonding in molecular complexes of M(NO2 – acac)n and with heterocyclic N-bases reported [-] in recent years.