This condition reversed an inhibition of DNA synthesis by ..

Other exposures may induce the synthesis of a protective protein in the body. The best example is probably metallothionein, which binds cadmium and promotes the excretion of this metal; cadmium exposure is one of the factors that result in increased expression of the metallothionein gene. Similar protective proteins may exist but have not yet been explored sufficiently to become accepted as biomarkers. Among the candidates for possible use as biomarkers are the so-called stress proteins, originally referred to as heat shock proteins. These proteins are generated by a range of different organisms in response to a variety of adverse exposures.

leading to the inhibition of DNA synthesis, ..

Rawat K (1979) Inhibition of cardiac protein synthesis by prolonged ethanol administration.

inhibition of the synthesis of new dna ..

Folic acid, heterocyclic bases and nucleotides are the building blocks for DNA and are made naturally within the cells. Agents under this category block one or other step in the formation of nucleotides, not permitting the synthesis of DNA and RNA in turn stopping the process of replication. Examples of drugs in this class include methotrexate (Abitrexate®), fluorouracil (Adrucil®),hydroxyurea (Hydrea®) and mercaptopurine (Purinethol®).

Effects of semicarbazide on DNA, RNA and protein …

The anticancer effects of thiosemicarbazones were once solely attributed to the inhibition of ribonucleotide reductase, an enzyme involved in the rate-limiting step of DNA synthesis. However, the mechanism behind this inhibition was initially not described. The ability of thiosemicarbazones to chelate metal ions has now been recognized as a major factor in their antiproliferative effects. The more reasonable explanation for the higher activity by the metal-thiosemicarbazone complexes when compared to free ligands passes through the prevalence of the diffusive mechanism over the active transport mechanism across the membranes. The chelation of the metal ion by the most polar regions of the ligands (the donor atoms) allows an easier uptake by the cell. In vivo analysis indicates that some thiosemicarbazones show potential as chemotherapeutic agents. However, future study is warranted.

The inhibition of cardiac microsomal protein synthesis by acetaldehyde.
Schreiber SS, Briden K, Oratz M, & Rothschild MA (1972) Ethanol, acetaldehyde, and myocardial protein synthesis.

DESIGNING, SYNTHESIS, SPECTRAL …

Given the apparent lack of physiological substrates, it is possible that P450 enzymes in families CYP1, CYP2, CYP3 and CYP4 that have appeared in the past several hundred million years have evolved as a means of detoxifying foreign chemicals encountered in the environment and diet. Clearly, evolution of the xenobiotic-metabolizing P450s would have occurred over a time period which far precedes the synthesis of most of the synthetic chemicals to which humans are now exposed. The genes in these four gene families may have evolved and diverged in animals due to their exposure to plant metabolites during the last 1.2 billion years—a process descriptively termed “animal-plant warfare” (Gonzalez and Nebert 1990). Animal-plant warfare is the phenomenon in which plants developed new chemicals (phytoalexins) as a defence mechanism in order to prevent ingestion by animals, and animals, in turn, responded by developing new P450 genes to accommodate the diversifying substrates. Providing further impetus to this proposal are the recently described examples of plant-insect and plant-fungus chemical warfare involving P450 detoxification of toxic substrates (Nebert 1994).

Since each compound inhibits a different enzyme in the process of DNA synthesis inhibition, ..

CHEMICAL HAZARD INFORMATION PROFILE DRAFT REPORT Semicarbazide ..

The results of EGFR inhibitory activity of the tested compounds were corresponding to the structural relationships of their anticancer activities. Magdy et. al synthesized different thio semicarbazide derivatives of 4-(3-(Benzofuran-2-yl)-1-phenyl-1H-pyrazol-4-yl)-2-hydrazinyl-1,6-dihydro-6-oxopyrimidine-5-carbonitrile, among which some were found to be quite effective against human liver carcinoma cell line (HEPG2).

There is evidence that the drug may act by inhibition of protein, RNA and DNA synthesis

Oral Administration of Semicarbazide Limits Weight …

Goals of investigation: In the present study employed chalcone (CL)moiety as the primary motif to achieve the inhibitory function which is appended with Semicarbazone and hydrazone pharmacophores as depictedin order to target intermediate kinases of the cell cycle. Conjugation of such ligands with copperis expected to endow antimicrobial property. The present study describes synthesis and characterisation of some chalcone analogues and their copper conjugation and evaluation of their antimicrobial activity.