Answers from specialists on woodward synthesis of cholesterol

Cellular lipid (re)synthesis [As the two fatty acids move into the enterocytes, they chemically react with coenzyme A (CoA) to form two fatty acyl coenzyme A molecules (fatty acyl-CoA); these two molecules combines with the monoacylglycerol that was also broken down and absorbed earlier to form a triacylglycerol molecule once again; the combination of various triacylglycerides, cholesterol, and other absorbed lipids come together with apolipoproteins to form a nascent chylomicron];

Statins inhibit cholesterol synthesis in the liver

Cholesterol synthesis ceases when the ATP ..

The Synthesis of Cholesterol : ..

For example, in ruminants dietary and carbohydrates fats are generally metabolized in the rumen so that the primary source of carbons for FA synthesis by the mammary gland are acetate and BHBA.

Cholesterol can be used for the synthesis of ..

Bile salts are secreted at a rate of 24 g/day, but synthesized at a rate of only 0.4 g/day in the average individual. This is because, once bile salts have completed their functions in the biliary tree and intestine, almost all are reabsorbed in the distal ileum and returned to the liver through portal venous circulation. Less than 5% of bile salts are lost in the feces each day, which amounts to about 0.4 g/day. The synthesis of bile salts in the liver is adjusted by the body to match the fecal excretion. Considering that cholesterol is the substrate for bile salt synthesis in the liver, a loss of 0.4 g/day of bile salts translates to a loss of the same quantity of cholesterol (i.e., 0.4 g/day).
p. into bile at the rate of up to 2 g/day. The average diet consists of about 0.4 g/day of cholesterol. Therefore, the amount of cholesterol that is derived from bile in the intestine is up to 5-fold in excess of the amount that is taken in through the diet. The biliary cholesterol and dietary cholesterol are admixed in the intestine to form a pool of cholesterol molecules that are indistinguishable. The average individual absorbs 50% of the cholesterol that passes through the intestine each day. This means that 50% is lost in the feces, amounting to 1.2 g/day.

The synthesis of cholesterol is also regulated by the amount of cholesterol …
squalene are some of the important intermediate compounds formed during cholesterol synthesis

The cyotoskeleton represents the cell's skeleton

Mineralocorticoid synthesis aldosterone pregnenolone produced biosynthesis of steroid hormones the adrenal steroid hormones are synthesized from cholesterol which is mostly derived lchsreunionfo

Purine nucleotide synthesis is regulated by feedback inhibitor – AMP, GMP and IMP. An important regulatory factor is the availability of PRPP.

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Cholesterol biosynthesis
80% of endogenous cholesterol is formed in the liver. Enzymes involved in the synthesis are partly located in the endoplasmic reticulum and partly in the cytoplasm. Acetyl CoA is the precursor. HMG CoA, mevalonate, isopentenyl pyrophosphate, squalene are some of the important intermediate compounds formed during cholesterol synthesis. Cholesterol is transported in lipoprotein complexes. Elevation of lipids in blood leads to the deposition of cholesterol on the arterial walls leading to atherosclerosis.

Rosuvastatin (Crestor) competitively inhibit HMG co-enzyme A reductase, a rate limiting step in cholesterol synthesis

of Dolichol-PP-oligosaccharide Synthesis

The Demark paper is consistent with healthy high LDL being a side-effect of HDL efficiency in a high-fat population, while unhealthy high LDL (or any LDL) will associate with poor HDL function.
Many people are diagnosed with CVD or T2DM over the age of 50, probably most are, there’s a bit of discussion around this in the paper. And the lowest LDL category,
As the statin use was voluntary not randomised it's hard to say what effect it had.