Nomenclature of Aldehydes and Ketones

N2 - A novel three-step synthesis of 3-aryl β-carbolin-1-ones from non-indole starting materials has been developed. The two nitrogen atoms in β-carbolin-1-one were introduced efficiently by Michael addition of ethyl acetamidocyanoacetate to chalcone. The desired pyridone and indole rings were assembled by an intramolecular ketone-nitrile annulation mediated by aqueous HCl-HOAc and a Cu(i)-catalyzed intramolecular N-arylation of the amide, respectively. The target compounds were found to possess significant activity against tumor cell proliferaton.

Synthesis of Aldehydes and Ketones

Reactions of Aldehydes and Ketones

Electrochemical synthesis of α-enaminones from aryl ketones

AB - 3-Aroyl-4-aryl-2-pyrazolines (21-40) have been synthesized by the reaction of α,β-unsaturated ketones (1-20) with diazomethane. These 2-pyrazolines gave β-methyl-α,β-unsaturated ketones (41-46) on thermal denitrogenation.

Synthesis of N-aryl enamino ketones | SpringerLink

AB - A novel three-step synthesis of 3-aryl β-carbolin-1-ones from non-indole starting materials has been developed. The two nitrogen atoms in β-carbolin-1-one were introduced efficiently by Michael addition of ethyl acetamidocyanoacetate to chalcone. The desired pyridone and indole rings were assembled by an intramolecular ketone-nitrile annulation mediated by aqueous HCl-HOAc and a Cu(i)-catalyzed intramolecular N-arylation of the amide, respectively. The target compounds were found to possess significant activity against tumor cell proliferaton.


Synthesis of Arylketones Using Envirocat EPZG Catalyst

The gold(I)-catalyzed Claisen-type rearrangement of cyclic 8-aryl-2,7-enyn-l-ols proceeds via a cationic allylic vinyl ether gold intermediate to give spirocyclic ketones. The reaction proceeded via attack of the hydroxyl group onto the gold-activated alkynes followed by [3,3]-sigmatropic rearrangement to generate the spirocyclic ketones. This transformation can be applied to the synthesis of aza- and oxaspirocyclic ketones from cyclic 8-aryl-2,7-enyn-l-ols bearing an N-sulfonamide or an oxygen atom linkage in the tether and the gold(I) catalyst.

Palladium-Catalyzed Synthesis of Aryl Ketones by …

Primary, secondary, and even tertiary alkyl groupswork as do aryl and alkenyl groups.























Transition-metal-catalyzed synthesis of phenols and aryl ..

Three-component catalyst effective for hydrogenation of simple ketones, composed of Ruthenium(II) complexes with phosphine ligands (or diphosphine), 1,2-diamine and strong base, was discoverd by NOYORI Molecular Catalysis Project of Exploratory Research for Advanced Technology (ERATO) organized by Japan Science and Technology Corporation (JST).

This catalyst catalyzes highly efficient hydrogenation of simple ketones. In addition to high activity, carbonylselective hydrogenation of aldehydes and ketones with conjugated or unconjugated carbon-carbon multiple bonds1), and diastereoselective hydrogenation of various ketones 2), 3) are performed smoothly under mild conditions, such as at room temperature and/or under low hydrogen-pressure(1-10atm), to give the corresponding alcohols in a nearly quantitative yields.
The use of chiral Ruthenium(II)-diphosphine complex, in combination with appropriate chiral diamine, catalyzes enantioselective hydrogenation of prochiral ketones to give chiral alcohols with a very high enantiomeric purity 1), 3), 4). Furthermore this catalyst is environmentally conscientious because of extremely high acitivity minimizing metal disposal after the reaction, compared with the stoichiometric reduction with metal hydride reagents, and the use of 2-propanol as a solvent 5). Exploitation and Application Study(participants : Nagoya University, Aich Institute of Technology, Tokyo Institute of Technology, Sumitomo Chemical Co., Ltd., Takasago International Corporation, Nissan Chemical Ind., Ltd., Nippon Soda Co., Ltd., and Kanto Chemical Co., Inc.) supported by JST has improved this catalyst into twocomponent catalyst : one of them is the shelf-stable and easy to handle Ruthenium(II) complexes, which have both of phosphine(or diphosphine) and 1,2-diamine ligands, and the other is strong base. We are now able to offer the ready-to-use Ruthenium(II) complexes for easy-handling and simpler preparation of catalyst in a laboratory. Two-component catalyst, which is composed of this improved Ruthenium(II) complexes and strong base, 6) has realized an exceedingly efficient hydrogenation of simple ketones, which rates and productivities from one to two orders of magnitude higher than those obtained with three-component catalyst 1)-4), keeping the high selectivity. We recommend this catalyst for the laboratory-use, as well as the improvement and development in your production process.

Reduction of Nitro Groups and Aryl Ketones

A novel three-step synthesis of 3-aryl β-carbolin-1-ones from non-indole starting materials has been developed. The two nitrogen atoms in β-carbolin-1-one were introduced efficiently by Michael addition of ethyl acetamidocyanoacetate to chalcone. The desired pyridone and indole rings were assembled by an intramolecular ketone-nitrile annulation mediated by aqueous HCl-HOAc and a Cu(i)-catalyzed intramolecular N-arylation of the amide, respectively. The target compounds were found to possess significant activity against tumor cell proliferaton.