Synthesis of Aldehydes and Ketones
Electrochemical synthesis of α-enaminones from aryl ketones
AB - 3-Aroyl-4-aryl-2-pyrazolines (21-40) have been synthesized by the reaction of α,β-unsaturated ketones (1-20) with diazomethane. These 2-pyrazolines gave β-methyl-α,β-unsaturated ketones (41-46) on thermal denitrogenation.
Synthesis of N-aryl enamino ketones | SpringerLink
AB - A novel three-step synthesis of 3-aryl β-carbolin-1-ones from non-indole starting materials has been developed. The two nitrogen atoms in β-carbolin-1-one were introduced efficiently by Michael addition of ethyl acetamidocyanoacetate to chalcone. The desired pyridone and indole rings were assembled by an intramolecular ketone-nitrile annulation mediated by aqueous HCl-HOAc and a Cu(i)-catalyzed intramolecular N-arylation of the amide, respectively. The target compounds were found to possess significant activity against tumor cell proliferaton.
Synthesis of Arylketones Using Envirocat EPZG Catalyst
The gold(I)-catalyzed Claisen-type rearrangement of cyclic 8-aryl-2,7-enyn-l-ols proceeds via a cationic allylic vinyl ether gold intermediate to give spirocyclic ketones. The reaction proceeded via attack of the hydroxyl group onto the gold-activated alkynes followed by [3,3]-sigmatropic rearrangement to generate the spirocyclic ketones. This transformation can be applied to the synthesis of aza- and oxaspirocyclic ketones from cyclic 8-aryl-2,7-enyn-l-ols bearing an N-sulfonamide or an oxygen atom linkage in the tether and the gold(I) catalyst.