Controlled drug release behavior of metformin …
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Hydrogel nanoparticles in drug delivery - ScienceDirect
Biodegradable materials are natural or synthetic in origin and are degraded in vivo, either enzymatically or non-enzymatically or both, to produce biocompatible, toxicologically safe by-products which are further eliminated by the normal metabolic pathways. The number of such materials that are used in or as adjuncts in controlled drug delivery has increased dramatically over the past decade. The basic category of biomaterials used in drug delivery can be broadly classified as (1) synthetic biodegradable polymers, which includes relatively hydrophobic materials such as the α-hydroxy acids (a family that includes poly lactic-co-glycolic acid, PLGA), polyanhydrides, and others, and (2) naturally occurring polymers, such as complex sugars (hyaluronan, chitosan) and inorganics (hydroxyapatite) [–]. The breath of materials used in drug delivery arises from the multiplicity of diseases, dosage range and special requirements that may apply. Biocompatibility is clearly important, although it is important to note that biocompatibility is not an intrinsic property of a material, but depends on the biological environment and the tolerability that exists with respect to specific drug-polymer-tissue interactions .
Polymers | An Open Access Polymer Science Journal …
A considerable amount of research has been conducted on drug delivery by biodegradable polymers since their introduction as bioresorbable surgical devices about three decades ago. Amongst all the biomaterials, application of the biodegradable polymer poly lactic-co-glycolic acid (PLGA) has shown immense potential as a drug delivery carrier and as scaffolds for tissue engineering. PLGA are a family of FDA-approved biodegradable polymers that are physically strong and highly biocompatible and have been extensively studied as delivery vehicles for drugs, proteins and various other macromolecules such as DNA, RNA and peptides [–]. PLGA is most popular among the various available biodegradable polymers because of its long clinical experience, favorable degradation characteristics and possibilities for sustained drug delivery. Recent literature has shown that degradation of PLGA can be employed for sustained drug release at desirable doses by implantation without surgical procedures. Additionally, it is possible to tune the overall physical properties of the polymer-drug matrix by controlling the relevant parameters such as polymer molecular weight, ratio of lactide to glycolide and drug concentration to achieve a desired dosage and release interval depending upon the drug type [–]. However the potential toxicity from dose dumping, inconsistent release and drug-polymer interactions require detailed evaluation. Here we present a review on the PLGA primarily as a delivery vehicle for various drugs, proteins and other macromolecules in commercial use and in research. We also present possible directions for future uses of PLGA in drug delivery applications.
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