FIG. 1: CHEMICAL STRUCTURE OF CINNAMALDEHYDE, C9H8O
Beneficial effects of cinnamaldehyde:
Composition: Cinnamon contains essential oils and all other compounds such as cinnamic acid, cinnamaldehyde and cinnamate 20. Cinnamaldehyde is the major component comprising 85% in the essential oil and the purity of cinnamaldehyde in use is high (> 98%). Both oil and pure cinnamaldehyde are equally effective in inhibiting the growth of various microorganism such as Gram-positive and Gram-negative (E. coli) bacteria, and fungi including yeasts, filamentous molds and dermatophytes 1, 26. Their minimum inhibition concentrations (MIC) values as determined by agar dilution method varied only slightly. The MICs range of both oil and cinnamaldehyde for bacteria is large. The antimicrobial effectiveness of oil and its major constituent is comparable and almost equivalent, which suggests that the broad-spectrum antibiotic activities of oil are due to cinnamaldehyde 27.
Keyword Cinnamaldehyde | Collection of Czechoslovak ...
Synthesis and formulation: There are several methods of laboratory synthesis of cinnamaldehyde is available, however it is most economically obtained from the steam distillation of the oil of cinnamon bark 2, 28. The compound can be prepared from the related compounds such as cinnamyl alcohol, (the alcohol form of cinnamaldehyde), but the first synthesis from unrelated compounds is the aldol condensation of benzaldehyde and acetaldehyde. In the cases of Bhanage et al., 1999, methyl-trans-cinnamaldehyde and cinnamaldehyde selectivity towards unsaturated alcohol reached 96% and 93% respectively high in supercritical carbon dioxide (scCO2) as a good solvent for selective production by hydrogenation.