1 The synthesis of compounds 1–18: ..

Seed oils consist mainly of triglycerides, that is, they comprise a unit of glycerol backbone esterified with three acyl groups (usually but not limited to C16–C18) which may be saturated or unsaturated with one or more olefinic functionalities per acyl group. Very rarely do seed oils contain additional functional groups, such as hydroxyls as in castor and lesquerella seeds. Milkweed seed oil follows the natural triglyceride patterns, but with a difference in being highly poly olefinic. This character allows for the introduction of different reactive groupings into the structure of the oil so as to be amenable to tailoring to a variety of uses. Synthesis of the milkweed polyhydroxy triglyceride (MWPHTG) from the polyoxirane triglyceride derivative of milkweed oil using in situ peroxy acid epoxidation of the oil was previously reported. Subsequent acidolysis of the epoxy derivative gave the MWPHTG. Here the polyhydroxy triglyceride was saponified for glycerol removal thus generating the polyhydroxy fatty acids of milkweed oil. Studies of the physical characteristics, flow and stability of the resulting hydroxylated fatty acids using FTIR, NMR, DSC, Rheometry and TGA indicate a stable material with unique properties that would be useful as additives in many applications such as pharmaceuticals.

Synthesis of polyhydroxy aromatic compounds

The polyhydroxy steroid compounds can be used for synthesizing certonardosterol D2.

Synthesis of Macrocyclic Polyhydroxy Tetralactams …

AB - A review on the elegant parts and significance of the total synthesis of useful bioactive compounds is presented. Enumerated and discussed are the total syntheses of cochleamycin A, natural products possessing fused aromatic rings, nitrogen-containing polyhydroxy compounds and trichostatin D. The total synthesis using both glycosylation under mitsunobu conditions and stereoselective vinylogous mukaiyama aldol reaction are also discussed.

Synthesis of polyhydroxy cavitands and ..

We examined the structure-activity relationship of the natural polyhydrowy aromatic compounds and synthesized a number of new derivetives through various methods.

Synthesis of Polyhydroxy Piperidines and Pyrrolidines Related to Carbohydrates

Defining chemical reactions of the polyphenol class

Two different protocols for the preparation of water-soluble, enantiomerically pure polyhydroxybisphospholanes from acid-labile acetal and -butyldimethylsilyl-protected derivatives are reported. These procedures circumvent two of the commonly encountered limitations in the synthesis of these potentially important ligands: (a) formation of phosphonium salts from the highly basic phosphine under acidic conditions, and (b) the need to start with preformed, fully protected cationic metal complex. Thus, cationic Rh complexes of these ligands have been prepared in a separate step, and they have been found to be excellent catalysts for organic and aqueous phase hydrogenation of dehydroamino acids. The viability of catalyst recovery has been demonstrated in three different systems, including two cases where > 99% ee can be achieved under recycling conditions.

Synthesis of Polyhydroxy-steroids

A review on the elegant parts and significance of the total synthesis of useful bioactive compounds is presented. Enumerated and discussed are the total syntheses of cochleamycin A, natural products possessing fused aromatic rings, nitrogen-containing polyhydroxy compounds and trichostatin D. The total synthesis using both glycosylation under mitsunobu conditions and stereoselective vinylogous mukaiyama aldol reaction are also discussed.

the formulator in the synthesis of the polyhydroxy fatty acid ..

This paper reviews the present state of enzyme-catalyzed acyltransfer reactions, which represent a highly useful method for the transformation of alcoholic and amino functional groups in a chemo-, regio- and enantioselective fashion. 1. Introduction 2. Acyl-Transfer Techniques 2.1. Quasi-Irreversible Acyl Donors 2.2. Irreversible Acyl Donors 2.3. Other Acyl Donors 3. Synthetic Applications 3.1. Separation of E/Z-Stereoisomers 3.2. Asymmetrization of Prochiral or meso-Diols 3.3. Enzymatic Resolution of Primary and Secondary Alcohols 3.4. Enzymatic Resolution of Labile Hydroxy Compounds 3.5. Regioselective Protection of Polyhydroxy Compounds 3.5.1. Enzymatic Acylation of Carbohydrates 3.5.2. Enzymatic Acylation of Natural Glycosides 3.5.3. Regio- and Chemoselective Acylation of Alkaloids 3.5.4. Regioselective Acylation of Polyhydroxy Steroids 4. Preparative Procedures 5. Final Remarks

Polyhydroxy alcohols are more soluble in water than …

N2 - A review on the elegant parts and significance of the total synthesis of useful bioactive compounds is presented. Enumerated and discussed are the total syntheses of cochleamycin A, natural products possessing fused aromatic rings, nitrogen-containing polyhydroxy compounds and trichostatin D. The total synthesis using both glycosylation under mitsunobu conditions and stereoselective vinylogous mukaiyama aldol reaction are also discussed.