Synthesis of polyhydroxy aromatic compounds
Synthesis of Macrocyclic Polyhydroxy Tetralactams …
AB - A review on the elegant parts and significance of the total synthesis of useful bioactive compounds is presented. Enumerated and discussed are the total syntheses of cochleamycin A, natural products possessing fused aromatic rings, nitrogen-containing polyhydroxy compounds and trichostatin D. The total synthesis using both glycosylation under mitsunobu conditions and stereoselective vinylogous mukaiyama aldol reaction are also discussed.
Synthesis of polyhydroxy cavitands and ..
We examined the structure-activity relationship of the natural polyhydrowy aromatic compounds and synthesized a number of new derivetives through various methods.
Defining chemical reactions of the polyphenol class
Two different protocols for the preparation of water-soluble, enantiomerically pure polyhydroxybisphospholanes from acid-labile acetal and -butyldimethylsilyl-protected derivatives are reported. These procedures circumvent two of the commonly encountered limitations in the synthesis of these potentially important ligands: (a) formation of phosphonium salts from the highly basic phosphine under acidic conditions, and (b) the need to start with preformed, fully protected cationic metal complex. Thus, cationic Rh complexes of these ligands have been prepared in a separate step, and they have been found to be excellent catalysts for organic and aqueous phase hydrogenation of dehydroamino acids. The viability of catalyst recovery has been demonstrated in three different systems, including two cases where > 99% ee can be achieved under recycling conditions.