Microwave-Assisted Peptide Synthesis

Dr. Sara Pellegrino is an Assistant Professor of Organic Chemistry at the University of Milano, Department of Pharmaceutical Sciences, Italy. She received her Ph. D in Medicinal Chemistry from the University of Milano in 2005. She has been visiting scientist at the University of Regensburg (Germany) in 2005-2006. Her research interests are the synthesis of peptides and peptide mimics, and their application in Material Science, Catalysis, Biochemistry and Medicinal Chemistry. She is author of more than 50 papers in peer-reviewed journals, of two patents filed, and of 60 communications at international conferences.

Microwave-assisted peptide synthesis:

Improvement of degree of resin swelling and of efficiency of coupling in solid‐phase synthesis
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Dr. Amita is a PhD in Pesticide Toxicology. Her present research focuses on a holistic approach to corrosion mitigation, development of self-healing polyelectrolyte/sol-gel based “Smart anti-corrosion coatings” for aerospace applications and corrosion sensor. Her group also focuses on the understanding of corrosion mechanism in the aluminum alloy AA2024, using first-principles calculations to re-tailor corrosion resistant coatings/ synthesize corrosion inhibitors. She has 5 US patents, 3 book chapters and 28 publications in peer reviewed journals. In addition to conference papers and invited talks. She has guided PhD & Master’s students. She is a member of several scientific societies, PhD thesis examiner and reviewer of corrosion journals.


Heterogeneous photo-catalysis is an advanced oxidation process (PAO), which has been the subject of numerous studies and applications, particularly using the commercial oxide of TiO2 (P25, Evonik). Zinc oxide (ZnO) has often been considered a valid alternative to TiO2 due to its good opto-electronic, catalytic and photochemical characteristics along with its low cost. In order to improve the photocatalytic performance of ZnO for practical applications, various types of synthetic approaches have been developed, including, among others, the hydrothermal / solvothermal growth method, sol-gel method, ultrasonic assisted method, deposition chemistry in vapor phase, etc. with the aim of preparing ZnO particles with different sizes and morphologies. However, all of these methods require relatively severe reaction conditions such as high temperature, sophisticated techniques, high purity of gases, adjustable gas flow, expensive raw materials, etc. Therefore, it is important to find a simple and cost-effective method for the synthesis of crystalline nano-particles of ZnO. For this reason, in the present work, the ZnO has been synthesized by three different procedures: conventional aqueous precipitation method, hydrothermal method (H) and microwave assisted method (MW). In all three processes, the same material is obtained, hydrocincite [Zn5(CO3) 2(OH)6], which evolves to crystalline ZnO after calcination thermal treatments. We investigated the effect of the calcination temperature, at the same time (2 h), on the optical, textural and structural properties. Photo-catalytic studies were performed using two selected substrates, Methyl Orange and Phenol, as toxic model substrates (one colorant and the other transparent). The catalysts prepared were characterized by several techniques: DRX, SBET, FE-SEM, TEM and UV-Vis (in diffuse reflectance mode).From the results of XRD, it has been possible to establish that a minimum difference between the relative intensities of exposed faces (I100 and I002) is a crucial factor to obtain good photocatalytic properties. This minimum difference is achieved, in our cases by thermal treatments of calcination at 400ºC, 2 h. When this temperature is chosen, there is no appreciable variation between the photocatalytic activities of the oxides of zinc obtained by the three processes, and there are small differences depending on the nature of the substrate chosen, which can be attributed to the textural differences between the oxides. In any case, the obtained zinc oxides show, for each substrate, photo-catalytic activities in the UV that are superior to those presented by the widely used commercial oxide TiO2 (P25) used as reference.

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Microwave-assisted Peptide Synthesis

The developed simple microwave assisted solvent-free method for the synthesis of Schiff bases using a wetting reagent (𝛽-ethoxyethanol) were found more efficient on overall performance compare to conventional method as desired. The microwave irradiation technique led to improvement in the yield of all the target compounds with reduction in their reaction byproducts. The microwave process also substantially reduced the overall process time as expected, by reduction in reaction time against the described conventional method.

parallel microwave-assisted synthesis.

Objective: To optimize microwave assisted solvent free synthesis of Schiff bases of aromatic aldehydes and aromatic amines (ethyl 4-aminobenzoate) by using wetting reagent 𝛽-ethoxyethanol. The goal of this study was to investigate the % yields and time required for the completion of reaction for Schiff bases by microwave and conventional conditions.

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Dr. Manoj B. Gawande received his Ph.D. degree in Chemistry in 2008 from Institute of Chemical Technology, Mumbai, India. After several research stays in Germany, South Korea, Portugal, and England, he recently worked as a Visiting Professor at CBC-SPMS, Nanyang Technological University, Singapore. Presently, he is senior researcher at RCPTM, Palacky University, Olomouc, Czech Republic. His research interests are nanocatalysis, design of nanocatalysts, and their applications in greener organic synthesis; he has published over 50 scientific papers.