US5856501A - Synthesis of thiazole derivatives - …

Gupta, "Synthesis and Antimicrobial Profile of Newer Schiff Bases and Thiazolidinone Derivatives", WASET- International Journal of Chemical, Nuclear, Metallurgical and Materials Engineering, Vol.

SYNTHESIS OF THIAZOLE DERIVATIVES

NEW DERIVATIVES OF Methods for synthesis of compounds with structure 2-hydrazino-thiazole.6.

Synthesis of Thiazole Derivatives and Evaluation of …

In this paper, we report the synthesis of TOTOBzl and TOTOEt together with the one- and two-dimensional 1H NMR investigations of complexes between these TOTO analogues and the dsDNA oligonucleotide d(CGCTAGCG)2.

Synthesis of Thiazole Derivatives—A Review - Pharma

Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The small and simple benzothiazole nucleus possesses numerous biological properties like - antitumor, antimicrobial, anti-inflammatory, anticonvulsant, and antidiabetic activities. These activities are also possessed by its substituted derivatives as well. The present review focuses on some commonly used easy procedures to synthesize the benzothiazole moiety and its derivatives, which comprise of different biological activities.


Bachelor of Pharmacy - AIMST University

Devmurari et al., prepared a series of seven substituted 2-phenyl benzothiazoles and substituted 1, 3-benzothiazole-2-yl-4-carbothioate derivatives. All synthesized novel compounds were screened for anticancer activity and compounds (1.13) and (1.14) showed very good anticancer activity 35.

SYNTHESIS AND BIOLOGICAL EVALUATION OF …

Cheng K, Xue JY, Zhu HL. Design, synthesis and an- tibacterial activity studies o thiazole derivatives as po- tent eckAS inhibitors. Bioorg Med Chem Lett 2013;23:4235-4238.

Categories: Synthesis of N-Heterocycles ..

Background and Objectives: Bacterial resistance to antibiotics has motivated the researchers to evaluate the novel anti-bac- terial compounds such as some thiazole and imidazole derivatives. Thereby, in this work, we investigated the anti-bacterial effects of one new thiazole and two new imidazole derivatives on Bacillus cereus, Listeria monocytogenes, Escherichia coli, Salmonella typhimurium, Proteus mirabilis and Shigella dysenteriae.
Materials and Methods: The thiazole and imidazole derivatives were dissolved in DMSO. The disk diffusion method was utilized to measure the growth inhibition zone diameter values, and the broth micro-dilution method was applied to deter- mine the minimum inhibitory concentration (MIC) values.
Results: The synthesized imidazole derivatives lacked any inhibitory effect against the tested bacteria. On the other hand, although the synthesized thiazole derivative showed no inhibitory effect against Bacillus cereus, Salmonella typhimurium, and Escherichia coli, it inhibited the growth of Proteus mirabilis, Shigella dysenteriae, and Listeria monocytogenes with the MIC values of 1000, 125, and 1000 µg/ml, respectively, and the growth inhibition zone diameter values of 9.3 ± 0.1, 15.6 ± 0.2, and 8.1 ± 0.0 mm, respectively.
Conclusion: The anti-bacterial effect of the synthesized thiazole derivative on Shigella dysenteriae, Proteus mirabilis and Listeria monocytogenes was proven. However, its inhibition effect against Shigella dysenteriae was more than that against the others. Many in-vitro and in-vivo experiments are required to evaluate the effects of this compound on the bacteria and the human body.

06/06/2014 · Review

Khalil A, Berghot M, Gouda M. Synthesis and anti- bacterial activity of some new thiazole and thiophene derivatives. Eur J MedChem 2009;44: 4434-4440.

2-pentyl thiophene, 4861-58-9 - The Good Scents …

The heterocyclic 2- aminothiazole has attracted widespread attention due to their diverse biological activities, including antibacterial, antifungal activity 4, 5, 6. In view of these observations, we herein report the synthesis of some novel 2- aminothiazole derivatives and evaluate their antimicrobial and antifungal activity.