# T1 - Lithium for maintenance treatment of mood disorders.

Calculate the U statistic as the smaller of Ua and Ub. For n2≤ 20, Mann-Whitney tables are used to determine the probability, based on the U, n1 and n2 values. This probability is then used to reject or fail to reject the null hypothesis. If n2 > 20, the distribution of U rapidly approaches the normal distribution and the following apply:

## THE SEROTONIN HYPOTHESIS OF MAJOR DEPRESSION

### The somatic marker hypothesis ..

For example, let us say that we wanted to test the 5-HIAA (a serotonergic metabolite) levels in the cerebrospinal fluid (CSF) of depressed individuals.

### The findings supported the mood maintenance hypothesis in ..

This is a test of independent samples. The measurements may be continuous data, but the underlying distribution is either unknown, or known to be non-normal. In either case, the data can be ranked and analyzed without the constraint of having to assume a known population distribution.
Example: Three different plants manufactured the same garment style. Variation in garment length was a customer concern. Length was measured to the nearest 1/4″. Within each plant, only four measurement increment values were obtained. This lack of measurement sensitivity indicated that ranking the data was preferred to assuming normality. The null hypothesis is that the population medians are the same. Ho: M1 = M2 =… = Mn. The following table shows data coded as deviations from a common reference value.

### The Controllers: A New Hypothesis of Alien Abduction

Example: At a textile plant, some years ago, the primary product was denim. An important customer characteristic was “hand.” That is, how the fabric drapes and feels to the touch. Traditionally, hand was evaluated by individuals (judges or inspectors) who had become experts over time by literally handling the fabric. The lab manager had obtained, on trial from the vendor, a “handleometer,” an instrument to objectively measure hand. She believed that the current subjective procedure for determining hand was too insensitive to change and ineffective in establishing a common customer specification. The plant manager, two department heads and a product engineer (the plant judgment panel) were opposed to the handleometer. They said that the handleometer only measures the bending moment of fabric while they recognized multidimensional aspects of hand: stiffness, friction, drape, etc. The two measuring systems were compared using an analytic technique to determine whether the four panel members represented a statistically homogeneous decision-making group. Secondly, to correlate the panel average ranking with the handleometer ranked values. Ten random samples from production were obtained. The panel members were to independently rank them from most to least with no ties (although the expanded procedure permits ties), 10 samples are to be independently ranked by 4 judges or inspectors for the sensory response variable, hand. The null hypothesis is that the judges rankings are independent of each other. The judges independently ranked the samples for the characteristic specified. The Kendall statistics are calculated:

### 'Vascular Depression' Hypothesis | JAMA Psychiatry | …

For example, it is known that when monozygotic twins are reared apart later in life, their unique experiences shape their psychopathologies, regardless of the fact they both share the same genetic makeup and that they both experienced the same original family environment.

### Hypothesis generation and maintenance ..

A frequent objection made to cognitivist theories is the “fearof flying” objection: propositional attitudes are neithernecessary nor sufficient for the existence of an emotion, since I maybe well aware that flying is the safest means of transport and yetsuffer fear of flying. (Stocker 1992). I may feel a twinge ofsuspicion towards my butler, and yet believe him to be utterlytrustworthy; conversely, I may judge that he is up to no good, and yetfeel nothing in the way of emotion. These examples suggest an analogywith perceptual illusions, which a correct belief sometimes quitefails to dispel. Such “recalcitrant emotions” seem to offer prettyconclusive evidence against the assimilation of at least some emotionseither to judgement or to belief (D'Arms and Jacobson 2003; Brady2009).